BLOOD CANCER | SOMATIC EVOLUTION | AGEING
Inside every body, an evolutionary story unfolds…
Our bodies are made up of trillions of cells. Far from being genetically identical, each cell accumulates genetic changes as we live and age. This ongoing process leaves behind a rich record of how our cells adapt, compete, and sometimes drive disease. In our lab, we use powerful genomics tools to trace the very origins of this evolution within. Understanding how it begins in healthy tissues, unfolds across a lifetime, and influences human health, disease and cancer.
The long-term effects of chemotherapy on normal blood cells.
Nature Genetics, July 2025
Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia.
Nature, April 2025
Clonal dynamics and somatic evolution of haematopoiesis in mouse.
Nature, March 2025
Latest News
19 August 2026
Jyoti Nangalia appointed Sanger’s first Faculty Chair for Clinician Scientists
Congratulations to Dr Jyoti Nangalia, who has been appointed as the Wellcome Sanger Institute’s first Faculty Chair for Clinician Scientists. The newly created role recognises outstanding clinician scientists whose research bridges laboratory science and patient care, reflecting Jyoti’s leadership in translating genomic discoveries into a better understanding of blood cancer.
July 2026
Congratulations to Dr Kudzai Nyamondo on her promotion to Staff Scientist
Wonderful news: Dr Kudzai Nyamondo has been promoted to Staff Scientist as of July 2026. Kudzai joined the lab as a Sanger-CRUK Excellence Postdoctoral Fellow and has made outstanding contributions to our work on the clonal trajectories of blood cancers.
Research
In our lab we study the DNA and epigenome from blood and other tissues from development to ageing, health to disease, and precancer to cancer.
PEOPLE
We are a diverse group of people with a passion for seeking new knowledge and understanding through scientific research at scale.
PUBLICATIONS
We publish in peer reviewed Journals and make our work open access, sharing data with the scientific community across the globe.
RESOURCES
In our work, we design and develop new methods and algorithms, all of which we publish and share with fellow scientists.